Impact of maternal obesity on fetal programming of cardiovascular disease.
نویسندگان
چکیده
The in utero environment is a key determinant of long-term health outcomes; poor maternal metabolic state and placental insufficiency are strongly associated with these long-term health risks. Human epidemiological studies link maternal obesity and offspring cardiovascular disease in later life, but mechanistic studies in animal models are limited. Here, we review the literature pertaining to maternal consequences of obesity during pregnancy and the subsequent impact on fetal cardiovascular development.
منابع مشابه
Intrauterine programming
In mammals, the intrauterine condition has an important role in the development of fetal physiological systems in later life. Suboptimal maternal environment can alter the regulatory pathways that determine the normal development of the fetus in utero, which in post-natal life may render the individual more susceptible to cardiovascular or metabolic adult-life diseases. Changes in the intrauter...
متن کاملMaternal and Fetal Outcomes in Pregnant Women with Cardiac Diseases Presenting to Shariati Hospital Cardiovascular Department from 21st March 2017 to 20th March 2018
Background: Cardiac diseases are considered as major cause of maternal mortality during pregnancy and account for about 10% of all maternal mortalities. Cardiac diseases cause complications for both mother and fetus. In this study, we evaluated the effects of cardiac diseases on pregnancy and vice versa. Three groups of complications were examined: complication of maternal heart (serious and li...
متن کاملDevelopmental programming of adult obesity and cardiovascular disease in rodents by maternal nutrition imbalance.
Studies on fetal undernutrition have generated the hypothesis that fetal programming corresponds to an attempt of the fetus to adapt to adverse conditions encountered in utero. These adaptations would be beneficial if these conditions prevail later in life, but they become detrimental in the case of normal or plentiful nutrition and favor the appearance of the metabolic syndrome. In this articl...
متن کاملIdentification and comparative analyses of myocardial miRNAs involved in the fetal response to maternal obesity.
Human and animal studies show that suboptimal intrauterine environments lead to fetal programming, predisposing offspring to disease in later life. Maternal obesity has been shown to program offspring for cardiovascular disease (CVD), diabetes, and obesity. MicroRNAs (miRNAs) are small, noncoding RNA molecules that act as key regulators of numerous cellular processes. Compelling evidence links ...
متن کاملPrenatal Programming and Epigenetics in the Genesis of the Cardiorenal Syndrome.
The presence of a group of interacting maladaptive factors, including hypertension, insulin resistance, metabolic dyslipidemia, obesity, and microalbuminuria and/or reduced renal function, collectively constitutes the cardiorenal metabolic syndrome (CRS). Nutritional and other environmental cues during fetal development can permanently affect the composition, homeostatic systems, and functions ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Physiology
دوره 30 3 شماره
صفحات -
تاریخ انتشار 2015